Mechanisms of azole resistance among clinical isolates of Candida glabrata in Poland
نویسندگان
چکیده
منابع مشابه
Mechanisms of azole resistance in petite mutants of Candida glabrata.
We previously showed that resistant colonies of Candida glabrata inside the azole inhibition zones had respiratory deficiency due to mutations in mitochondrial DNA. Here, we analyzed the mechanisms of azole resistance in petite mutants of C. glabrata obtained by exposure to fluconazole or induced by ethidium bromide. The respiratory deficiency of these mutants was confirmed by oxygraphy and flo...
متن کاملProteomic analysis of azole resistance in Candida albicans clinical isolates.
Changes in protein expression within a matched set of Candida albicans isolates representing the acquisition of azole resistance were examined by two-dimensional polyacrylamide gel electrophoresis and peptide mass fingerprinting. Proteins differentially expressed in association with azole resistance included Grp2p, Ifd1p, Ifd4p, Ifd5p, and Erg10p, a protein involved in the ergosterol biosynthes...
متن کاملazole-resistant Candida glabrata
Case report-Subjects-Three cases are described oflong-standing vaginal candidosis due to Candida glabrata. These had failed to respond to local and systemic antifungals. In each case the infecting strain appeared resistant to a range of azole drugs in vitro. Clinical course-Case one-This patient recovered following prolonged treatment with oral itraconazole in combination with oral and vaginal ...
متن کاملMechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China.
OBJECTIVES To explore the mechanisms underlying azole resistance in clinical isolates of Candida tropicalis collected in China by focusing on their efflux pumps, respiratory status and azole antifungal target enzyme. METHODS Fifty-two clinical isolates of C. tropicalis were collected from five hospitals in four provinces of China and antifungal susceptibility tests were performed. Rhodamine 6...
متن کاملOccurrence of killer Candida glabrata clinical isolates
In this work we characterized the occurrence of killer activity in 64 Candida glabrata clinical isolates under different conditions. We found that only 6.25 % of the clinical isolates tested were positive for killer activity against a Saccharomyces cerevisiae W303 sensitive strain. Sensitivity of killer activity to different values of pH and temperatures was analyzed. We found that the killer a...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 2015
ISSN: 0022-2615,1473-5644
DOI: 10.1099/jmm.0.000062